By E. D. Thomas (auth.), Prof. Dr. T. Büchner, Prof. Dr. W. Hiddemann, Priv. Doz. Dr. B. Wörmann, Prof. Dr. G. Schellong, Prof. Dr. J. Ritter (eds.)
The premiums of acute leukemia treatment have steadily better over the past decade. medical examine effects mirror the effect of chemotherapy depth and period, the function of lengthy upkeep, intensified consolidation or very early intensification. extra development has additionally been accomplished in bone marrow trans plantation, and up to date potential experiences and meta-analyses have contributed comparisons of the excessive antileukemic efficacy of bone marrow transplantation to that of greater chemotherapy. this enables a extra profitable combining of the 2 types of therapy. New prognostic components have emerged from either cytogenetic and molecular genetic study. hence, the Philadelphia chromosome translocation and the bcr/abl gene rearrangement have confirmed to be the dominating hazard consider acute lymphoblastic leukemia. because the frequency raises with age, changes in diagnosis among teenagers and adults might be defined. review of molecular and immunologic leukemia phone markers has supplied a greater figuring out of residual leukemia in medical remission, as a prognostic issue and in tracking the effectiveness of the antileukemic technique. fresh paintings on leukemic mobile biology has ended in novel healing methods reminiscent of terminal differentiation via all-trans-retinoic acid, modulation of chemotherapy by means of hematopoietic progress components corresponding to GM-CSF and enhancement of immunologic regulate through cytokines equivalent to interleukin 2. New antimicrobial medicines and the applying of regularly empiric anti-infectious suggestions have helped decreasing the healing danger. hence, a few contemporary achievements have supplied us with new suggestions within the administration of sufferers with acute leukemias.
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Additional resources for Acute Leukemias IV: Prognostic Factors and Treatment Strategies
Hematology Service, University of Bari, Viale L. Einaudi, 111/0, 70125 Bari, Italy SPECCHIA, K. Department of Pediatrics II, University of Ulm, Prittwitzstral3e 43, 89075 Ulm, Germany STAHNKE, STARK, B. Sambur Center, Pediatric Hematology/Oncology, Beilinson Medical Center, Petah Tiqva 49100, Israel R. Fred Hutchinson Cancer Research Center, 1124 Columbia Street, Seattle, WA 98104-2092, USA STORB, SUTOR, A. H. Department of Pediatrics, University of Freiburg, Hugstetter St. 55, 79106 Freiburg, Germany D.
2, lower curve), the risk increased dramatically only during the first two-three years, after which time the rate of leukemia decreased markedly. Among our 20 cases of t-MDS and t-AML in Hodgkin's disease, no further cases were observed seven years after cessation of chemotherapy. If evaluated from start of chemotherapy, the steadily increasing risk up to 10 years relates to many late onset cases of t-MDS and t-AML in patients retreated for relapse of Hodgkin's disease. Cytogenetic Characteristics in 91 Consecutive Cases of t-MDS and t-AML Since the first report of monosomy 5 and monosomy 7 as highly characteristic for t-MDS and t-AML , these two abnormalities and loss of various parts of the long arms of the same two chromosomes (5q- and 7q-) have been observed in 50-80% of patients with t-MDS and t-AML [25-28].
Gerardo, V. Donizetti, 106, 20052 Monza, Italy 2 Section of Molecular Biology, Department of Pediatrics II, University of Ulm 3 Divisione Ematologia, Ospedale Riuniti di Bergamo and Istituto Ricerche Farmacologiche "M. Negri" 4 Dipartimento di Biopatologia, Divisione Ematologia, I Universita di Roma 5 Clinica Medica Universita di Perugia genetics, cell culture systems, immunological markers analysis and molecular biological techniques . More recently the development of polymerase chain reaction (PCR) strategies has opened new possibilities towards the detection of MRD at frequencies of one in 1 x 104 to one in 1 x 105 .