By Masayasu Hiraoka, International Congress on Electrocardiol
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Additional info for Advances in Electrocardiology 2004: Proceedings of the 31th International Congress on Electrocardiology (Advances in Electrocardiography)
Crampton) but over the years the Registry expanded to include LQTS enrolment centers in Jerusalem, Israel (Dr. Jesaia Benhorin), Salt 11 Lake City, UT (Dr. Michael Vincent), and Houston, TX (Dr. Jeffrey Towbin) and a second center in Pavia (Dr. Silvia Priori). Challenges for the Future Additional new genes and new genetic mechanisms need to be uncovered, modifier genes that explain the variable duration of ventricular repolarization andor the variable severity of clinical manifestations in individuals with the same mutation have yet to be identified, gene-specific and mutation-specific therapy is presently in its infancy.
Nogami 841 Endocardia1 ElectroahatomicalSubstrate and Catheter Ablation in Patients with Nonischemic Cardiomyopathy and Monomorphic Ventricular TachycGdia K. Satomi 852 Author Index 855 1 Long QT Syndrome This page intentionally left blank 1979-2004 :25 YEARS OF THE INTERNATIONAL REGISTRY FOR THE LONG QT SYNDROME. ITS IMPACT ON KNOWLEDGE AND CLINICAL MANAGEMENT PETER J. SCHWARTZ Department of Cardiology IRCCS Policlinico S. Mafteo and Universiv of Pavia, Pavia, Italy Correspondence to: Peter J.
This is where the Registry, with its many large families and myriad of small families together with a quantitative QTc diagnostic marker and well defined clinical phenotypes, played a decisive role in offering molecular biologists ideal material on which to carry out their analyses. It was on this background that Mark Keating and his associates made their fundamental discoveries (2-4). It seems fair to say that in modem cardiology there have been few findings that have had such fruitful consequences as the identification of the first three LQTS genes.